A combination trial of intradermal radiofrequency and hyaluronic acid filler for the treatment of nasolabial fold wrinkles: A pilot study

Date:Jan 05, 2018

Within the last few years, hyaluronic acid (HA) fillers and radiofrequency (RF) devices have shown significant promise for 

skin rejuvenation. But the effects of HA only lasted for a relatively short duration. Therefore, we tried a new combination 

therapy of intradermal RF and HA filler. Objective: To evaluate the clinical efficacy of combination therapy of intradermal 

RF and HA filler for nasolabial fold (NLF) wrinkle reduction. Materials and methods: Ten Korean female volunteers with mild 

to severe NLFs were enrolled. In the control group, five subjects were treated with HA filler alone. In the experimental 

group, the other five subjects were treated with intradermal RF prior to HA filler. Efficacy was evaluated based on the 

change on the Wrinkle Severity Rating Scale (WSRS) and the Global Aesthetic Improvement Scale (GAIS) from baseline. 

Results: At 12 and 24 weeks after treatment, the experimental group showed significantly greater improvement in mean WSRS 

score compared to the control group. And two (40%) of the five patients in the experimental group achieved ‘very much 

improved’ and two (40%) showed ‘much improved’ at 12 weeks after treatment. Conclusions: Intradermal RF treatment prior 

to HA filler injection may provide synergistic and long-lasting effects for the reduction of NLF wrinkles.

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